Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• properties of drug carriers. Keywords: atomic force microscopy; drug delivery; elasticity; mechanical properties; nanomedicine; nanoparticles; stiffness measurement; tissue/body distribution; Introduction Drug delivery systems are developed with the aim to transport a given drug to the site of action

Effect of sample treatment on the elastic modulus of locust cuticle obtained by nanoindentation

• Chuchu Li,
• Stanislav N. Gorb and
• Hamed Rajabi

Beilstein J. Nanotechnol. 2022, 13, 404–410, doi:10.3762/bjnano.13.33

• ). The specimens were indented using a SA2 Nanoindenter (MTS Nano Instruments, Oak Ridge, TN, USA) equipped with a Berkovich diamond tip. The elastic modulus of the specimens was measured using the continuous stiffness measurement (CSM) technique. CSM is a well-established technique for obtaining the

Scanning speed phenomenon in contact-resonance atomic force microscopy

• Christopher C. Glover,
• Jason P. Killgore and
• Ryan C. Tung

Beilstein J. Nanotechnol. 2018, 9, 945–952, doi:10.3762/bjnano.9.87

• zero scan speed and the equation for the effective sample stiffness keff. The experimental percent error in the stiffness measurement is calculated using the difference between the measured sample stiffness at zero scan speed and at non-zero scan speeds. Figure 5 shows both the experimental and

Assembly of metallic nanoparticle arrays on glass via nanoimprinting and thin-film dewetting

• Sun-Kyu Lee,
• Sori Hwang,
• Yoon-Kee Kim and
• Yong-Jun Oh

Beilstein J. Nanotechnol. 2017, 8, 1049–1055, doi:10.3762/bjnano.8.106

• , nanoindentation measurements were conducted. The measurements were performed using a nanoindentation system (MTS Nano-indenter XP) equipped with continuous stiffness measurement using a Berkovich indenter, and the elastic modulus and nanohardness were calculated using the method of Oliver and Pharr [32]. The

Dynamic nanoindentation by instrumented nanoindentation and force microscopy: a comparative review

• Sidney R. Cohen and
• Estelle Kalfon-Cohen

Beilstein J. Nanotechnol. 2013, 4, 815–833, doi:10.3762/bjnano.4.93

• performed on isotactic polypropylene (iPP, 127,000 g/mol) by using instrumented nanoindentation (Agilent DCM) and AFM tip based nanoindentation (NTMDT NTEGRA). A typical INI load-vs-displacement curve is displayed in Figure 5A. The modulation results (continuous stiffness measurement CSMTM, modulation

• the continuous stiffness measurement (CSM) induces a frequency-dependent phase shift. Consequently, a correction of the phase shift is required. The calibration is made according to the protocol described by Herbert et al. [64]: With the indenter tip hanging in free space the stiffness and the damping

Characterization of the mechanical properties of qPlus sensors

• Jan Berger,
• Martin Švec,
• Martin Müller,
• Martin Ledinský,
• Antonín Fejfar,
• Pavel Jelínek and
• Zsolt Majzik

Beilstein J. Nanotechnol. 2013, 4, 1–9, doi:10.3762/bjnano.4.1

• mass, and therefore it has certainly a negative effect on the resonant frequency. The interesting question is whether this kind of tip attachment has a significant effect on the stiffness measurement. In the following part of the text, the effective stiffness will be shown in brackets right after the

• Boltzman constant (kB = 1.38 × 10−23 J·K−1), T is the temperature of the system (in our case it is RT) and k is the stiffness of the tuning fork. This method can be used for stiffness measurement if the oscillation is only thermally excited without any additional excitation (for instance mechanical

• in Equation 5 as a square value, the error in the stiffness measurement will be two times higher than the error in the amplitude. Stiffness values that were calculated from the thermal noise of the sensor are summarized in Table 3. Comparison of the methods We found good agreement between calculated